Peer-Review vs. Info Prizes and Markets

I have been having a 140 character discussion with Ciarán Brewster (@macbruski) via twitter.  And while it’s kind of interesting to force complex subject matter into very few characters, it is limiting the discussion, so I will summarize it so far here and hopefully others can weigh in too.…

The Conflict Between Complex Systems and Reductionism

The following is a recent paper by Henry Heng published in JAMA.  I’ve linked concepts mentioned in the paper to corresponding explications from this blog.

JAMA. 2008;300(13):1580-1581.
The Conflict Between Complex Systems and Reductionism
Henry H. Q. Heng, PhD
Author Affiliations: Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan.

Descartes’ reductionist principle has had a profound influence on medicine. Similar to repairing a clock in which each broken part is fixed in order, investigators have attempted to discover causal relationships among key components of an individual and to treat those components accordingly. …

Autism and Mercury

A recent study funded by the Centers for Disease Control and Prevention (CDC) in Atlanta claims that thimerosal, a mercury-based preservative used for many years in vaccines, is “not associated with problems in speech, intelligence, memory, coordination, attention, or other measures of childhood development.” For those unaware of the thimerosal controversy, it has been claimed by many that it causes or is a factor in the development of autism. Michael Goldstein, vice president of the American Academy of Neurology said of the CDC study that it was, “enough to convince me that this small amount of mercury … was not harmful to the children.”

However, there is a glaring problem with this study. While it seemed comprehensive with respect to thimerosal exposure, it apparently did so by combing health plan records, not by attempting to measure levels of mercury in the actual bodies of the children or their mothers during pregnancy.…