Biological Immortality

There’s a scientific paradox in the world of nutrition about what the optimal diet is.  A new theory may resolve the paradox.  Oh, and help you live forever too.

The majority consensus is the “post-agricultural revolution diet” is best, which says that a majority of your intake should be vegetables and fruits, and that you should severely limit your animal product intake, especially red meats.  Some proponents (like T. Colin Cambell of China Study fame) go as far as claiming that a strictly vegan diet is best.

The other camp argues for the “paleo” or “caveman” diet, which says we need to eat what our paleolithic ancestors ate: lots of foods high in animal fat and animal protein, and avoid industrialized grains altogether (some fermented natural grains are fine).  Fermented foods in general are encouraged, honoring the fact that before preservation, refrigeration and pasteurization we evolved a symbiosis with bacterias that are critical for our digestion and processing of nutrients.

Both sides agree that processed …

Sunlight vs. Vitamin D

[This is part 3 of Epidemiology vs. Etiology]

You may have heard there is an epidemic of low vitamin D levels in the U.S.  An estimated 60% of Americans are at a level that has been correlated with increased risk of nearly all chronic diseases, including cancer, heart disease, diabetes, autoimmune diseases, and depression.  My personal belief is that the epidemiology is horribly flawed.  But perhaps not in the way you might think….

As most people know by now, we humans photosynthesize vitamin D in our skin when it is exposed to direct sunlight.  How fast depends on our ethnicity and amount of exposure.  Since I’m light skinned and get a lot of sun in my normal life, it came as a huge surprise when some routine bloodwork I had done about 9 months ago indicated I was “dangerously low.”

My doctor immediately prescribed large doses of vitamin D supplement, but I was convinced that the result was spurious.  Perhaps it was due to …

Medicine 2.0

Kim Scheinberg sent me a great article from The Atlantic that relates to my multi-thread rant on epidemiology.  Since the article speaks for itself, I’m just quoting points I think are salient.  The only words below that are not a direct quote are the headlines (i.e. “Did you know?”).  The emphasis is mine as well.

Did you know?

  • mammograms, colonoscopies, and PSA tests are far less useful cancer-detection tools than we had been told
  • Zoloft, and Paxil were revealed to be no more effective than a placebo for most cases of depression
  • staying out of the sun entirely can actually increase cancer risks
  • taking fish oil, exercising, and doing puzzles doesn’t really help fend off Alzheimer’s disease

Medicine has caught a plague

we think of the scientific process as being objective, rigorous, and even ruthless in separating out what is true from what we merely wish to be true, but in fact it’s easy to manipulate results, even unintentionally or unconsciously.

There is an

Epidemiology vs. Etiology

Over the last several years I’ve been digging into the science of cancer and systems biology, while at the same time looking at the epidemiology of disease and nutrition.  And the more I learn, the more I’m convinced that there’s a gap that our scientific tools and methodologies cannot account for.  While I’ve discussed this generally under the heading of Science 2.0 (also here), I’ve had a hard time putting into language the exact nature of the gap.

I’ve begun a series of posts that I hope will illustrate the gap, which I believe has to do with the fundamental difference between epidemiology (which is based on statistical observation) and etiology (which seeks to find causal mechanisms for observed phenomena):

Once I’ve completed these posts, I’ll attempt to explain the nature of the gap and what it means for the future of scientific inquiry.…

A1 vs. A2 Milk

Large scale epidemiological studies have linked casein (a cow’s milk protein) to autoimmune disease and heart disease (see The China Study).  I just ran across the following twist on this theme which purports to explain a mechanism: a genetic mutation many years ago in domesticated cows transformed the original, safe casein (“A2”) into a toxic form (“A1”).  Most cow’s milk available today has both.

What do people think of this?  Has anyone tried personally to ingest milk products that are exclusively A2?

Given the dubious connection between cholesterol and heart disease, could the bad rap on cheeses, cream and ice cream have more to do with A1 and sugar than the animal fat and cholesterol?…

Will You Die From Cancer?

Use the arrows that appear if you hover over the bottom right of the Prezi.  You may want to expand to full screen first.

All feedback welcome.  If you like this, what subject would you like to see addressed next using Prezi?…

The Most Important TV Show in America

Remember Jamie Oliver’s TED Prize Wish?  Well tonight is the prime time season premiere of his Food Revolution show on ABC.  The Huffington Post called Undercover Boss the most subversive show in America, and I can’t disagree.  But in terms of importance to the future of America (and by extension every country which imports American TV and culture), Food Revolution I can’t imagine a more important show.

It’s not just the lives of individuals who eat crap (which is most of the country, frankly, even though they have no idea how toxic what they are eating is).  It’s the happiness and achievement potential of today’s youth.  It’s the emperor with no clothes at the center of the healthcare debate.  And it’s a lynchpin for economic recovery and sustainability.

Watch the premiere, and spread the word……

TED Prize Wish: Teach Every Child About Food

How Many Calories for a Dollar?

Michael Pollan, as always, making perfect sense:

Now watch Will Allen on urban farming…

Egyptian Mummies Yield Ancient Secrets of Good Journalism

This is based on an LA Times article here

What strikes me most is how athlerosclerotic the science itself is.  Or perhaps it’s just the reportage?

The opening line of the article is “CT scans of Egyptian mummies… show evidence of… hardening of the arteries, which is normally thought of as a disease caused by modern lifestyles….”  One of the researching cardiologist draws this conclusion: “Perhaps atherosclerosis is part of being human.”

The LA Times reporter covering the story (Thomas Maugh) rightly points out at the end, “The high-status Egyptians ate a diet high in meat from cattle, ducks and geese, all fatty.”  Which of course entirely negates the hypothesis of heart disease being part of the natural human condition.

It’s clear why the researchers — both cardiologists — would want ancient evidence to support the notion that heart disease is normal.  But the fact is that the preponderance of evidence around the world in epidemiology as well as cardiology indicates that …

The Link Between Food & Healthcare Reform

Also must-read this Sunday is Michael Pollan’s NY Times Op-Ed piece from Wednesday.  Nice cap to my week of ranting on the dismantling of rationality when it comes to lifestyle choices that directly impact one’s health, here and here.…

Rafe Issues Challenge to Statin Industry

I have been trying to get the straight scoop on whether statins actually decrease mortality and morbidity in a significant way and I haven’t been able to find any real evidence that they do.

If you ask a cardiologist it’s clear that they believe unequivocally that statins work, mostly because they see what statins to do blood cholesterol levels.  But remember, cholesterol numbers in and of themselves do not matter.  They are a proxy variable for cardiovascular health.  Plaque buildup matters.  At one time blood cholesterol numbers were the only non-invasive indicator we had of plaque buildup, but that’s not true anymore.  However, drug companies are highly incentivized to prove that statins improve health.  So they fund lots of studies.

Notwithstanding the systemic bias when there are profit motives and publication motives, we can turn to these studies and see if statins actually work.  The best way to remove bias is to look at large-scale meta-analyses, like this one.  If you simply read the …

The Problem With Processed Foods

By design, most processing concentrates certain nutrients and biochemicals while removing others.  This skews the natural ratios that we have evolved to eat.   This leads to two phenomena which, over many years, seems like a bad idea to subject one’s body to:

  1. Over-concentration: Just because a little bit of something is harmless or even healthy for you, doesn’t mean that large quantities are better.  Often times it’s worse for you, and even toxic.  While supplements are an extreme example of this — consider Vitamin D toxicity, which is something that only happens if you get it in supplement form — processed foods in general can take a food which is a net positive and turn it into a net negative.  So, whereas whole oranges you can eat quite a bit of and improve your health, drinking lots of orange juice is bad for you (the sugar content badness outweighs the micronutrient goodness).
  2. The missing 99.99%: There are tens of thousands of phytochemicals and other micronutrients

I’m a Nutritarian

For the past year or so I’ve been eating about 80% vegan.  I hate the word “vegan” because it has political/ideological connotations I don’t ascribe to, and also because by definition that’s not what I am.  I think Dr. Fuhrman’s neologism, nutritarian sums up my position on food choices:

A person who [eats for health] is called a nutritarian, and understands that food has powerful disease–protecting and therapeutic effects and seeks to consume a broad array of micronutrients via their food choices. It is not sufficient to merely avoid fats. It is not sufficient for the diet to have a low glycemic index. It is not sufficient for the diet to be low in animal products. It is not sufficient for the diet to be mostly raw food. A truly healthy diet must be micronutrient rich and the micronutrient richness must be adjusted to meet individual needs. The foods with the highest micronutrient per calorie scores are green vegetables, colorful vegetables, and fresh fruits. For

Something Fishy About Mercury

Here is a fascinating discussion on NPR’s Forum from earlier this year on the subject of mercury and fish:

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If you’ve listened to this the whole way through (which you should), I’m curious as to how it will affect your habits, if at all.  And why?…

Should We Tax Poor Nutrition?

I just tweeted on a subject that I suspected would cause a stir, and so it has, I’m moving it here:

RafeFurst: I strongly support a soda tax! RT @mobilediner: check it out:  a Soda Tax?

coelhobruno: @RafeFurst what about diet soda? Would it be exempt?

RafeFurst: @coelhobruno no diet soda would not b exempt from tax.  Tax should be inversely proportional to total nutritional content.  Spinach = no tax

Lauren Baldwin: I do as well … and while they are at it they should tax fake fruit juice too.

Kevin Dick: I think this would be an interesting experiment. I predict a tax does not cause any measurable decrease in BMI.

Kim Scheinberg: New York has had this under consideration for a year.  Perhaps surprisingly, I’m against it. In theory, people will drink less soda. In reality, it will just be another tax on people who can afford it the least.

Leaving aside the “rights” issues and …

Is Hunger Really a Problem in U.S.?

Given everything I hear about obesity stats in the U.S. and malnutrition in the developing world, the last thing I was expecting to find in my inbox this morning was a plea to join a Facebook cause to help end hunger in America.  Really?

I’m usually not skeptical in this way, and I’m loath to focus on the negative when it comes to philanthropy, but I can’t get these thoughts out of my head and I’d like some perspective from those who are better informed about the alleged U.S. hunger crisis.  In the mean time, here’s my food for thought:…

Decrease Red Meat Consumption

This is not news, health professionals of all sorts have been saying this for a long time.  ABC News features a recent study supporting this.

A relevant footnote near the end of the article though:…

Crohn's Disease

Debbie Maier asks us on the Upcoming Topics page to address Crohn’s Disease.

I don’t know too much about it except that it’s an autoimmune disease and has a complex, multi-causal etiology and pathology.  In my reading on autoimmune diseases in general there seems to be a direct link between latitude an incidence.   Specifically, the farther from the equator you live the more likely you are to get Crohn’s, Type 1 diabetes, rheumatoid arthritis, and so on.…

Coffee Linked to Lower Dementia Risk

The NY Times reports.

Here’s my theory:  someone who drinks more than three cups of coffee a day can’t possibly sit still and actually gets their ass off the couch and does shit, thereby stimulating the body and brain, a known and powerful way to reduce dementia risk.

hat tip: Daniel Horowitz

Great Nutrition Tips

I’ve plugged Dr. Ann before on this blog, but this 13 minute video is definitely worth checking out, esp. during the holidays.  Ignore the marketing and just listen to the information and tips.  The science of nutrition is extremely complex, but there are some well-understood principles that Dr. Ann focuses on.  If you are like me, you have to understand the processes before you will believe something and take action.  I think her book is the best out there as it’s a combination of scientific consensus, practical tips, and easy-to-understand explanations of why the recommendations work.…